Paul Szauter, PhD, Chief Scientific Officer, EquiSeq – Page 2

German Warmblood Associations Include Testing for EquiSeq Genetic Variants in Genotyping Platform

Albuquerque, New Mexico The International Association of Future Horse Breeding (IAFH), a group of five German Warmblood associations, has developed a large-scale genotyping platform (a SNP array) for breed improvement. They have added tests for the variants in EquiSeq’s Myopathy Panel to the array. Results will be available to horse owners through Generatio GmbH –…

Horse Breeding Associations Support Genetic Research on PSSM2

Vechta, Germany PSSM2 (Polysaccharide Storage Myopathy Type 2) is a much discussed topic. Now the horse breeding associations for Holstein, Trakehner, Hanoverian, Oldenburg and Westphalia want to make genetic material available for research purposes to a project of the International Association of Future Horse Breeding GmbH & Co KG (IAFH). Muscle wasting, lameness, stiff gait,…

EquiSeq’s Chief Scientific Officer Speaks to Entrepreneurs

Albuquerque, New Mexico Paul Szauter, PhD, Chief Scientific Officer of EquiSeq, will present via Zoom at One Million Cups in Albuquerque on Wednesday, January 20, at 9:00 am MST. The format is a six-minute presentation followed by twenty minutes of questions and discussion. The presentation is open to the public via Zoom. Based on the notion that entrepreneurs…

Genetic Linkage of P8 and K1

How can you figure out the chances of different genotypes when breeding horses? Monohybrid Cross It’s easy for one gene. Let’s say that there is a stallion that has one copy of one of the genetic variants associated with PSSM2, the P2 variant (MYOT-S232P). This stallion is heterozygous (n/P2), meaning that he has one normal…

Generatio GmbH – Center for Animal Genetics Adds P8 and K1 Tests

Tubingen, Germany Generatio GmbH – Center for Animal Genetics (CAG) has added the P8 variant of PYROXD1 and the K1 variant of COL6A3 to its Variant Panel. These tests are now available to horse owners in the EU and UK. The launch followed licensing of these tests from EquiSeq. Generatio GmbH – Center for Animal…

The K1 Genetic Variant Affects COL6A3, a Gene Encoding a Collagen

Contents Introduction The K1 genetic variant that has been part of EquiSeq’s Myopathy Panel since October 2019 is a missense allele of COL6A3, a gene encoding a collagen [1]. Collagens are a family of proteins that are the main structural components of the connective tissue. Collagens also guide bone formation and play an important role in…

The P8 Genetic Variant Affects PYROXD1, a Gene Required for Oxidative Defense

Contents Introduction The P8 genetic variant that has been part of EquiSeq’s Myopathy Panel since October 2019 is a missense allele of PYROXD1, a gene required for oxidative defense [1]. Mutations of the human PYROXD1 gene are associated with Myofibrillar Myopathy 8 in humans [1]. The P8 allele of equine PYROXD1 changes an aspartic acid (D) to a histidine (H),…

Podcast and Videos Explore Muscle Disease

Albuquerque, New Mexico July 2020 was a great month for horse owners seeking to understand muscle disease. Eden River Equestrian interviewed Paul Szauter, EquiSeq’s Chief Scientific Officer, for episode 86 of their Come Along for the Ride podcast. In the interview, Dr. Szauter talked about the effects of the genetic variants that are included in EquiSeq’s Myopathy…

Peer Review Fails to Identify Errors in Inconclusive Study of Genetic Variants of Equine Muscle Genes

This blog post is a discussion of a paper published by Williams et al. in a recent issue of Equine Veterinary Journal [1]. The paper aims to identify genetic variants that might be responsible for Myofibrillar Myopathy (MFM) in Warmbloods. The authors use a candidate gene approach, searching for variants of eight of the nine genes known…

Genetic Basis of Exercise Intolerance in Arabians

Paul Szauter, PhD, Chief Scientific Officer of EquiSeq, gave a presentation titled “Genetic Basis of Exercise Intolerance in Arabians” at the Al Khamsa Annual Meeting and Convention in Fayetteville, Arkansas on October 13, 2019. EquiSeq is a company based in Albuquerque, New Mexico, that develops and sells genetic tests for horses. Exercise intolerance is known…